2005: #2 - "Lose Control"

Dominated by a memorable, eerily familiar sounding and somewhat nerve-wracking sample, and anchored by a starmaking guest appearance from the great Ciara, "Lose Control" was, sadly, the last in nearly a decade-long run from hip-hop/R&B hitmaker and electro-pop pioneer Missy Elliott. If not for an extraordinarily surprising #1, this would have been yet another Missy song that far surpassed anything else being done sonically, melodically and rhythmically in pop music.